This article, an excellent review, whose lead author is Robert Myers, MD, editor of the Journal of the Peripheral Nervous System and a leading researcher into the role of TNF-alpha and neuroinflammation, cited our article:
Edward Tobinick MD and Susan Davoodifar MD,
Efficacy of etanercept delivered by perispinal administration for chronic back and/or neck disc-related pain: a study of clinical observations in 143 patients. [Case Reports, Journal Article]
Curr Med Res Opin 2004 Jul; 20(7) :1075-85.
Title The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets.
Author(s) Myers RR, Campana WM, Shubayev VI
Institution Department of Anesthesiology (0629), University of California-San Diego, La Jolla, CA 92093-0629, USA. rmyers@ucsd.edu
Source Drug Discov Today 2006 Jan; 11(1-2) :8-20.
MeSH Animals
Cytokines
Humans
Neuralgia
Neurogenic Inflammation
Peripheral Nerves
Abstract Neuroinflammation is a proinflammatory cytokine-mediated process that can be provoked by systemic tissue injury but it is most often associated with direct injury to the nervous system. It involves neural-immune interactions that activate immune cells, glial cells and neurons and can lead to the debilitating pain state known as neuropathic pain. It occurs most commonly with injury to peripheral nerves and involves axonal injury with Wallerian degeneration mediated by hematogenous macrophages. Therapy is problematic but new trials with anti-cytokine agents, cytokine receptor antibodies, cytokine-signaling inhibitors, and glial and neuron stabilizers provide hope for future success in treating neuropathic pain.
Language eng
Pub Type(s) Journal Article
Review
PubMed ID 16478686
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